Dear Colleague,
I inform you that there will be the online Department discussion on Tuesday, 13th April, 2021 from 08:30 on the Zoom.
Professor Panyi urges that EVERYONE can login, however if you can't do it please send me an email to biophys@med.unideb.hu .
The lecturer is Prof. Dr. Zoltán Papp (Division of Clinical Physiology, Department of Cardiology, UD), title: " ACE/ACE2 balance, cardiovascular diseases and COVID-19"
Abstract:
The role of the renin-angiotensin-aldosterone system in cardiovascular disease (CVD) has been established. Elevated levels of angiotensin II produced by angiotensin converting enzyme (ACE) have adverse effects on the cardiovascular system, while angiotensin 1-7 produced by angiotensin converting enzyme type 2 (ACE2) mediates protective effects. The SARS-CoV-2 virus (following a proteolytic priming process) binds to its cellular receptor, ACE2. Virus adherence and invasion is facilitated by the function of proteases (transmembrane protease serine 2, cathepsin-L, furin) of the host tissue. Based on the above, dysregulation in ACE/ACE2 balance and tissue specific proteases play central roles not only in the development of CVDs but also in SARS-CoV-2 infections. However, the related signalling processes are currently unknown. The severity of COVID-19 has been associated with age, cardiovascular disease (CVD, i.e. hypertension and heart failure), type 2 diabetes (T2DM), male gender, obesity, and a number of other chronic clinical conditions (e.g., chronic kidney disease, COPD, smoking, malignancies, etc.). The recognition of CVD-specific changes in the ACE/ACE2 balance and spike protein proteases is greatly complicated by the multitude of interacting factors. Taken together, tissue-specific regulatory disturbances in the ACE/ACE2 balance is of major importance in the development of cardiovascular disease (CVD) and the high mortality of COVID-19.