Using advanced microscopy, Pialy Sen and her coworkers in the research group of György Vámosi found that cells lacking lamin A had smaller nuclei and altered chromatin organization, while agonist ligand (rosiglitazone) induced activation of PPARγ, an important regulator of lipid metabolism, caused chromatin to become more open. They also showed that PPARγ binds DNA more strongly when lamin A is absent, suggesting that lamin A normally helps control gene activity by organizing chromatin and regulating access of transcription factors to DNA. The results were published in Biophysical Journal.
Pialy Sen, Anshu Kumar Sharma, Arpan Chowdhury, Éva Hegedüs, László Imre, Ibtissem Benhamza, Julianna Volkó, Péter Szűcs, László Nagy, Gábor Szabó, Péter Nagy, Katalin Tóth, György Vámosi: Lamin A depletion and RSG influence PPARγ DNA binding and chromatin organization in murine adult fibroblast cells. Biophys J. 2026