An easy-to-use method offer insights into the organization of cellular membranes of individual, intact living cells and can be used to identify affected organelles and therapeutic targets in diseases with alterations in membrane lipid composition.
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The research conducted by Lőrinc Nagy, Gábor Nagy, Tamás Juhász, Csaba Fillér, Gabriella Szűcs, Zoltán Szekanecz, György Vereb, Péter Antal-Szalmás, and Árpád Szöőr provides critical insights into the mechanisms underlying systemic sclerosis (SSc).
New opportunities in cancer therapy: CAR-NK cells against solid tumors
Kipchumba Biwott, Zsolt Bacso, and their colleagues at the University of Debrecen studied the expression of the P-glycoprotein (Pgp/ABCB1) multidrug transporter in human CD8+ T lymphocytes during their differentiation.
Epigenetic modulation via the C-terminal tail of H2A.Z
Ghofrane Medyouni , Péter Hajdu and their colleagues in collaboration with Cellular and Molecular Therapy group at the University of Debrecen studied the activity of potassium channels in CAR T cells.
Synergistic effect of folic acid and hypericin administration to improve the efficacy of photodynamic therapy via folate receptors
In their recently published study, Dr. Florina Zakany and her colleagues investigated the effects of these lipids on KV1.3, a functionally relevant ion channel of immune cells.
Investigations on a cellular model system by László Ujlaky-Nagy, János Szöllősi and György Vereb may offer additional information on the expected outcome of pertuzumab therapy
The study of receptor distribution patterns is important for investigating receptor systems and characterizing them as potential therapeutic targets.