News

Modulators of the Human Voltage-Gated Proton Channel Hv1

The proton channel Hv1 is a protein in cell membranes that moves protons (a type of charged particle) in and out of cells.

H2A.Z

H2A.Z-containing nucleosomes can assume either a stable or an unstable configuration depending on the presence or absence of the C-terminal nonapeptide of the variant histone (Z1 or Z1∆C, respectively).

Functional role of Kv1.3 localization in chimeric antigen receptor T cells

Functional role of Kv1.3 localization in chimeric antigen receptor T cells

Ruxolitinib Modulates P-Glycoprotein Function, Delays T Cell Activation, and Impairs CCL19 Chemokine-Directed Migration in Human Cytotoxic T Lymphocytes

Ruxolitinib Modulates P-Glycoprotein Function, Delays T Cell Activation, and Impairs CCL19 Chemokine-Directed Migration in Human Cytotoxic T Lymphocytes

Fluorescence labeling causes global changes in antibody structure and dynamics through the hydrophobic effect

Fluorescence labeling causes global changes in antibody structure and dynamics through the hydrophobic effect

The plasma membrane actively influences ligand concentrations in its immediate vicinity

The plasma membrane is a dynamic structure surrounded by the extracellular matrix. Although stimulation of transmembrane proteins by soluble ligands takes place in this environment, its influence on receptor activation is usually overlooked.

Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion Centruroides villegasi

Kashmala Shakeel, Gyorgy Panyi, and their colleagues, in collaboration with Prof. Possani’s research group at UNAM, Mexico, are exploring peptide toxins that block specific potassium channels.

Role of CAR-T cell K+ channels in tumor infiltration and elimination

Vivien Jusztus, Árpád Szöőr and Péter Hajdu investigated the role of CAR-T cell potassium channels in tumor infiltration and elimination.

EGFR- HER2 Transactivation Viewed in Space and Time Through the Versatile Spectacles of Imaging Cytometry—Implications for Targeted Therapy

Investigations by László Ujlaky-Nagy, János Szöllősi, and György Vereb using complementary biophysical approaches on cellular model-systems may offer mechanistic insights into therapies targeting EGFR-HER2 interactions

Metal–organic framework nanoparticles carrying hypericin for anti-SARS-CoV-2 and antibacterial photodynamic therapy

Metal–organic framework nanoparticles carrying hypericin for anti-SARS-CoV-2 and antibacterial photodynamic therapy