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Metal–organic framework nanoparticles carrying hypericin for anti-SARS-CoV-2 and antibacterial photodynamic therapy

Metal–organic framework nanoparticles carrying hypericin for anti-SARS-CoV-2 and antibacterial photodynamic therapy

The publication „Look Beyond Plasma Membrane Biophysics: Revealing Considerable Variability of the Dipole Potential Between Plasma and Organelle Membranes of Living Cells” by Mate Szabo, Bence Cs.Szabo, Kitti Kurtan, Zoltan Varga, Gyorgy Panyi, Peter Nagy, Florina Zakany and Tamas Kovacs can be read in full length in the International Journal of Molecular Sciences.

An easy-to-use method offer insights into the organization of cellular membranes of individual, intact living cells and can be used to identify affected organelles and therapeutic targets in diseases with alterations in membrane lipid composition.

New opportunities in cancer therapy: CAR-NK cells against solid tumors

New opportunities in cancer therapy: CAR-NK cells against solid tumors

Dynamic P-glycoprotein Expression in Early and Late Memory States of Human CD8+ T Cells and the Protective Role of Ruxolitinib

Kipchumba Biwott, Zsolt Bacso, and their colleagues at the University of Debrecen studied the expression of the P-glycoprotein (Pgp/ABCB1) multidrug transporter in human CD8+ T lymphocytes during their differentiation.

Epigenetic modulation via the C-terminal tail of H2A.Z

Epigenetic modulation via the C-terminal tail of H2A.Z

Ghofrane Medyouni , Péter Hajdu and their colleagues in collaboration with  Cellular and Molecular Therapy group at the University of Debrecen studied the activity of potassium channels in CAR T cells.

Ghofrane Medyouni , Péter Hajdu and their colleagues in collaboration with Cellular and Molecular Therapy group at the University of Debrecen studied the activity of potassium channels in CAR T cells.

Uptake of FA-Hyp-SBA-15 nanoparticles in HeLa cells and their efficiency in photodynamic therapy

Synergistic effect of folic acid and hypericin administration to improve the efficacy of photodynamic therapy via folate receptors

Membrane ceramides modulate the activation gating of the voltage-gated potassium channel KV1.3

In their recently published study, Dr. Florina Zakany and her colleagues investigated the effects of these lipids on KV1.3, a functionally relevant ion channel of immune cells.

Disrupting EGFR–HER2 Transactivation by Pertuzumab in HER2-Positive Cancer: Quantitative Analysis Reveals EGFR Signal Input as Potential Predictor of Therapeutic Outcome

Investigations on a cellular model system by László Ujlaky-Nagy, János Szöllősi and György Vereb may offer additional information on the expected outcome of pertuzumab therapy

Novel Transmission Electron Microscopic Method to Quantify Protein Clustering on the Cell Surface

The study of receptor distribution patterns is important for investigating receptor systems and characterizing them as potential therapeutic targets.